SL-164 CN Export – Wholesale

SL‑164 (Dicloqualone): A Quinazolinone Sedative/Hypnotic for Advanced Research

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🧬 Overview

SL‑164 (5‑chloro‑3‑(4‑chloro‑2‑methylphenyl)‑2‑methylquinazolin‑4‑one), also known as Dicloqualone, is a synthetic quinazolinone derivative developed in the late 1960s by Sumitomo. Designed as a structural analogue of methaqualone (Quaalude), SL‑164 exhibits sedative, hypnotic, and muscle-relaxant properties. Though never approved for clinical use due to its higher risk for convulsions, it serves as a valuable molecular tool in neuroscience and forensic toxicology.

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⚙️ Chemical & Physical Properties

• IUPAC Name: 5‑Chloro‑3‑(4‑chloro‑2‑methylphenyl)‑2‑methylquinazolin‑4‑one
• Molecular Formula: C₁₆H₁₂Cl₂N₂O
• Molecular Weight: ~319.19 g/mol
• Physical Form: Crystalline powder, soluble in DMF, DMSO, ethanol

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🧠 Mechanism of Action

SL‑164 acts as a positive allosteric modulator at GABAₐ receptors, enhancing inhibitory chloride flux—similar to methaqualone and barbiturates—producing sedative-hypnotic effects. It also has anticonvulsant activity, but with a notable risk of seizure induction at high doses.

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📌 Pharmacological Profile

Sedative & Hypnotic Effects

In preclinical studies, SL‑164 induced sedation and hypnosis akin to methaqualone, though never advanced due to seizure risk.

Anticonvulsant Activity

Early rodent models demonstrated seizure suppression, but adverse events and convulsions hindered further development .

Toxicology & Clinical Incidents

Two documented intoxications (ages ~21–22) involved high doses (~300 mg orally), resulting in agitated delirium, myoclonus, tachycardia, and prolonged sedation, managed by supportive care and benzodiazepines.

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💊 Dosage & Administration (Research Context)

SL‑164 is used solely in analytical-standard or animal-study settings. No human clinical dosing exists. If administered in vivo, start with microgram–milligram doses in rodents, via injection or oral gavage. Always follow ethical and legal guidelines

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⚠️ Side Effects & Safety

• CNS: Sedation, ataxia, cognitive impairment
• Paradoxical Excitation: At high doses—delirium or convulsions
• Autonomic: Tachycardia, hypertension in overdose
• Respiratory/CV: Risk low, but depressed in severe poisoning cases

Use in controlled experiments with seizure monitoring and emergency protocols.

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🔒 Harm Reduction & Lab Safety

• Prepare accurate stock solutions, store at −20 °C
• Use mg-precision scales
• Avoid co-administration with CNS depressants
• Ensure supportive care measures available for convulsions

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🔖 Legal and Research Status

• Not marketed clinically; research-use only
• Cheaper online supply spurred designer-drug misuse
• Regulatory status varies; legal under medicinal or analogue drug laws

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🧪 Summary

SL‑164 is a chemically intriguing and biologically significant sedative-hypnotic agent with both utility and risk. Serving as a methaqualone analogue, it carries GABAergic potency, experimental value, and forensic importance. Use within approved lab protocols only.

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★ We have a long trading history in the market so you benefit from our experience.
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What you will receive when you buy SL‑164 CN Export from RECHEMCO?

• One sealed aluminum foil bag containing highest grade SL‑164 CN Export
• White powder
• 99% Purity