Fluoprazolam Freebase CN Export – Wholesale

Fluoprazolam – Piperazinyl-Substituted Benzimidazodiazepine

---

🧬 Overview

Fluoprazolam is a potent synthetic benzimidazo[1,2-a][1,4]diazepine derivative, structurally distinct from both alprazolam and flualprazolam. It incorporates:

• A 2-fluorophenyl substitution
• An 8-nitro group on the benzimidazo core
• A 4-methylpiperazin-1-ylmethylene moiety at position 2

This unique substitution pattern is designed to modulate GABA_A receptor affinity while altering physicochemical properties such as lipophilicity, CNS penetration, and metabolic stability.

---

⚛️ Chemical Identity

• IUPAC Name: (Z)-6-(2-fluorophenyl)-2-((4-methylpiperazin-1-yl)methylene)-8-nitro-4H-benzo[f]imidazo[1,2-a][1,4]diazepin-1-one
• Molecular Formula: C₂₂H₂₁FN₆O₃
• Molecular Weight: ~448.46 g/mol
• Chemical Class: Benzimidazo[1,2-a][1,4]diazepine (nitro-substituted)

---

⚙️ Pharmacology

As a benzodiazepine-class ligand, Fluoprazolam is presumed to act as a positive allosteric modulator at the GABA_A receptor benzodiazepine site. Binding enhances the effect of endogenous GABA, increasing neuronal chloride influx, leading to:

• Sedative-hypnotic effects
• Anxiolysis
• Anticonvulsant activity
• Muscle relaxation

The piperazinylmethylene side chain may alter receptor subtype selectivity or confer additional pharmacokinetic changes (e.g., slower metabolism).
The nitro group in benzodiazepine analogs is often associated with longer half-life and high receptor affinity.

---

📈 Pharmacokinetics (based on class data, specific studies on Fluoprazolam limited)

• Onset: Likely within 30–60 minutes (oral)
• Duration: Estimated 8–14 hours (possible residual sedation)
• Metabolism: Hepatic, probable CYP3A4 involvement
• Excretion: Urinary metabolites after oxidative and reductive transformations

---

⚠️ Effects & Risks

Potential desired effects (at controlled research doses):

• Profound sedation
• Reduced anxiety
• Anticonvulsant action
• Sleep induction

Adverse effects / overdose symptoms:

• Respiratory depression
• Severe motor incoordination
• Memory blackouts
• Hypotension
• Prolonged unconsciousness

Given the likely high potency, sub-milligram active quantities are plausible, requiring extreme caution in measurement and handling.

---

❗ Harm Reduction for Laboratory Use

• Always weigh with 0.1 mg analytical balances or use volumetric dilution
• Avoid inhalation/dermal exposure — use PPE and fume hood
• Store securely to prevent unauthorized access
• Keep away from heat, light, and moisture

---

🔬 Research Applications

Fluoprazolam’s unusual piperazinylmethylene substitution makes it a valuable reference for:

• Structure–activity relationship (SAR) studies within benzodiazepines
• Pharmacokinetic modeling of bulky side chain effects
• Forensic standard for analytical testing of seized samples

---

🌍 Legal Status

While specific scheduling varies, most jurisdictions control nitrobenzodiazepines under psychotropic substance laws or analog provisions.
Researchers must confirm local legality before acquisition or handling.

---

📌 Summary

Fluoprazolam is a high-affinity benzimidazodiazepine with a distinctive structure, likely potent CNS depressant effects, and long duration. Its profile makes it important in forensic toxicology and benzodiazepine receptor research, but also demands stringent safety protocols.

---

Why Buy Fluoprazolam from RECHEMCO?

★ We have a long trading history in the market so you benefit from our experience.
★ Fluoprazolam was tested and verified.
★ We accept various payment methods such as Bitcoin, the main cryptocurrencies, Credit Card via Plisio and bank wire.

What you will receive when you buy Fluoprazolam from RECHEMCO?

• One sealed aluminum foil bag containing highest grade Fluoprazolam
• white/yellowish powder
• 99% Purity