Anastrozole is a potent non-steroidal aromatase inhibitor that is used in the treatment of breast cancer in postmenopausal women. This drug works by inhibiting the activity of the aromatase enzyme, which is responsible for converting androgens into estrogens in peripheral tissues.
Anastrozole is available as an oral tablet that is typically taken once daily. The recommended dose of Anastrozole is 1 mg per day, which may be adjusted based on individual patient factors such as age, weight, and disease severity. Anastrozole can be taken with or without food, but it is important to take the medication at the same time each day to maintain consistent blood levels.
Anastrozole has been shown to significantly reduce the risk of breast cancer recurrence in postmenopausal women with hormone receptor-positive breast cancer. This drug has also been shown to decrease the incidence of contralateral breast cancer in these patients.
Anastrozole has a favorable side effect profile compared to other hormone therapies used in the treatment of breast cancer. Common side effects of Anastrozole include hot flashes, joint pain, and vaginal dryness. Rare but serious side effects may include bone fractures, cardiovascular events, and liver dysfunction.
Before starting Anastrozole, it is important to inform your healthcare provider about any other medications you are taking, as well as any pre-existing medical conditions such as liver disease, osteoporosis, or heart disease. Anastrozole is not recommended for use in premenopausal women, as it may interfere with the normal functioning of the ovaries.
In conclusion, Anastrozole is a highly effective and well-tolerated medication that is used in the treatment of hormone receptor-positive breast cancer in postmenopausal women.