2-Methyl-PiHP (2-Me-PiHP) is a novel synthetic compound belonging to the pyrrolidine class of stimulants. Structurally related to α-Pyrrolidinohexiophenone (α-PiHP), 2-Me-PiHP exhibits similar pharmacological effects but features a methyl substitution at the 2-position of the phenyl ring. This minor structural modification significantly impacts the compound’s receptor affinity, potency, and duration of action. 2-Me-PiHP is primarily researched for its central nervous system (CNS) stimulating properties, often compared to cathinone derivatives such as α-PVP and α-PiHP. Due to its unique chemical profile, it is widely used in pharmacological studies exploring the mechanisms of stimulant-induced dopamine release and norepinephrine uptake inhibition.
Chemical Structure and Properties
- IUPAC Name: 2-(Methylamino)-1-phenylpentan-1-one
- Molecular Formula: C13H17NO
- Molecular Weight: 203.28 g/mol
- SMILES Representation: CC(C)NC(=O)C1=CC=CC=C1
- Chemical Class: Pyrrolidine Stimulant
2-Me-PiHP is a highly lipophilic compound, enabling it to cross the blood-brain barrier efficiently. Its pharmacodynamics involve high-affinity binding to monoamine transporters, particularly the dopamine and norepinephrine transporters (DAT and NET), resulting in potent reuptake inhibition and increased synaptic neurotransmitter levels.
Effects
The effects of 2-Me-PiHP, based on anecdotal reports and laboratory studies, include:
- Stimulation: Enhanced physical and mental energy, often accompanied by heightened alertness and focus.
- Euphoria: A transient increase in mood and feelings of well-being.
- Increased Sociability: Users report heightened confidence and talkativeness.
- Cognitive Enhancement: Improved short-term memory, problem-solving abilities, and concentration.
The onset of effects is typically rapid, occurring within 15-30 minutes after administration, with peak effects observed around 1-2 hours. The total duration of action ranges from 4 to 6 hours, depending on dosage and individual metabolic factors.
Dosage Guidelines
Disclaimer: All information is provided for research purposes only. Human consumption is not advised.
- Threshold: 5-10 mg
- Light: 10-20 mg
- Common: 20-30 mg
- Strong: 30-40 mg
Due to its potency, initial doses should be conservative to mitigate adverse reactions. Laboratory protocols should emphasize precise measurement using a milligram scale.
Side Effects
Potential adverse effects include:
- Psychological: Anxiety, paranoia, agitation, and restlessness.
- Physical: Increased heart rate, hypertension, sweating, and vasoconstriction.
- Neurological: Headache, dizziness, and insomnia.
Prolonged or excessive use may exacerbate side effects, leading to tolerance, dependence, or neurotoxicity. Researchers should exercise caution during studies to limit dosage and exposure duration.
Harm Reduction
To ensure safe handling and minimize risks, the following harm reduction strategies are recommended:
Co-administration: Avoid mixing with other stimulants or depressants to reduce interaction risks.
Accurate Dosage: Utilize calibrated equipment for precise measurement.
Environment: Conduct experiments in a controlled and supervised setting.
Hydration: Maintain proper hydration levels to mitigate dehydration caused by excessive stimulation.
Breaks: Avoid repeated exposure and ensure adequate rest periods between experiments.
Why Buy 2-Me-PiHP CN from RECHEMCO?
★ We have a long trading history in the market so you benefit from our experience.
★ 2-Me-PiHP was tested and verified.
★ We accept various payment methods such as Bitcoin, Monero and bank wire.
What you will receive when you buy 2-Me-PiHP from RECHEMCO?
• One sealed aluminum foil bag containing highest grade 2-Me-PiHP
• white/yellowish crystals
• 98% Purity
Lygelll (verified owner) –
Reactions in beakers gave interesting results. Short lasting bubbling. Clear solution compared to the murkier APIHP but could undeniably cause respiratory penalities once the research is complete…
benejichaser (verified owner) –
I was very much surprised by this to say the least. In a positive, I might add.
Likely is able to hold up to the high expectations, some might have, when it comes to this specific class.
Atleast, considering my expectations, that has been the case.
Rechemco –
Thank you for sharing your experience with our product. We’re pleased to hear it met your expectations for research purposes.
We want to remind all customers that our products are intended solely for laboratory research and analysis by qualified professionals. They are not for human consumption or any other unauthorized use.
Proper safety protocols should always be followed when handling any chemical substances. If you have any questions about appropriate research applications, don’t hesitate to contact us.
daggada (verified owner) –
If you Look around the net, the reviews for this substance are often reserved. After accidentially consuming some of this substance in connection with an erotic situation, the effect and the potential became obvious to us. It was pretty …. extatic.
Rechemco –
Thank you for sharing your experience and review. We’re glad to hear you had a positive encounter with the product, but we’d like to remind you that our products are strictly not intended for human consumption. Safety is our top priority, and we always recommend using the item as directed for its intended purpose.
If you have any questions about proper usage, feel free to reach out. Stay safe!
sweg9m12 (verified owner) –
i am very satisfying with the results and the effects of this chemical, honestly …since a-phip disappear, this chem. i s very close. ATTENTION! be very careful, strong and pure.
Rechemco –
Thank you for your feedback! We’re glad to hear you’re satisfied with the product. However, we’d like to remind everyone that all our chemicals are strictly for research purposes only and should be handled with extreme caution due to their potency and purity.
Always follow proper safety protocols and legal regulations when handling any research materials. Stay safe and responsible!
Researcher (verified owner) –
High quality Product – perfect for Research purposes
viktorialindinger8 (verified owner) –
Nochmal kurz bevor ich eine Bewertung abgeben möchte ich alle bitten in den Rezensionen sich an das halten was der Administrator gesagt hat und zwar oft genug! das ist alles nicht zum Konsum gedacht wenn ihr trotzdem noch Fragen habt dann per Mail … ich will diesen Shop wegen so einen blödsinn für mein Labor nicht verlieren ..!!
🌟⭐️⭐️🌟⭐️
Top Produkt sehr interessante Substanz und top admin ! Gratuliere 🥳 dir Fragen per Mail werden schnell beantwortet gebe aufjedenfall heute oder morgen wenn mein Geld drauf ist spätestens am 1. werde ich ganz sicher gleich eine neue Bestellungen aufgeben! Vielen Dank 🥺❤️
viktorialindinger8 (verified owner) –
Meine neue Lieblings Substanz …. Interessanter als als 3 F pihp meiner Meinung nach ❤️
Rechemco –
Translation of the comment (German → English):
“My new favorite substance… In my opinion, more interesting than 3-F-PiHP ❤️”
Answer in German:
Hallo und vielen Dank für dein Feedback!
Wir freuen uns sehr, dass dir dieses Produkt so gut gefällt. Wir bieten eine breite Auswahl an Substanzen an, sodass jede Art von Forschung und jeder Forscher das Passende finden kann. Danke für deine Unterstützung!
Bitte denk daran, dass alle verkauften Produkte reine Research Chemicals sind, nicht für den menschlichen oder tierischen Konsum bestimmt. Für jede Untersuchung sind geeignete Sicherheitsmaßnahmen und eine präzise Waage erforderlich.
Answer in English:
Hello and thank you for your feedback!
We’re very happy to hear this has become one of your favorite compounds. We offer a wide selection of products to ensure that all types of research and all researchers can find something suitable for their needs. Thank you for your support!
Please remember that all products sold are Research Chemicals, not intended for human or animal consumption. Proper research safety procedures and a precise scale are required.
micke forsberg (verified owner) –
Its for last order deliverd in October 2025.
I give it potency, that i can appreciate. But durance is lacking a bit, as most pv:s are this struggeling times. Feel i need quite a substancial amount to be where i want to be with this cimpound. Active, yes and a bit weak, to weak to impress. BUT, BUT, Rechemcos quality excels!!
If i get my order from a very troubled postal organisation in…. you know 😀, then i revalue again, if different batch.
Fly high…land softly friends.
Matti Kallio –
this 2-methyl-pihp wasnt The best alternative but not The worst!? i liked MDPIHP Better and oh yes that vape Even better so Maybe i try Combining these two Maybe thats The bomb For better vaping experience dunno??
Rechemco –
Hello and thank you for your review!
Different compounds have different chemical profiles, so it’s normal that researchers may prefer one over another depending on their research goals. 2-Me-PiHP and MDPiHP are different molecules, and each can produce different outcomes during experimentation. In the end, preferences often come down to the specific type of research being conducted.
Thank you for sharing your feedback and for your support.
Please remember that all products sold are Research Chemicals, not intended for human or animal consumption. Proper research safety procedures and a precise scale are required.
d9a (verified owner) –
It is an interesting substance that does not readily induce paranoid states (at least not for very long) and tends to sit on the milder side of the effect spectrum, while still being relatively potent. The perceived intensity varies substantially across routes of administration; inhaled use is generally preferable I would say, and I particularly recommend inhalation via a glass bong. Depending of course on the research. In all cases however use a milligram scale.
It was worth the wait. Just don’t count on it showing up in your mailbox within three weeks. Stay calm and give it time.
It was a pleasure doing business with Rechemco!
Rechemco –
Hello and thank you very much for your detailed review!
We appreciate your thoughtful observations and your emphasis on careful measurement and research discipline. As you mentioned, compounds in this category can vary significantly depending on the research setup and methodology, so using a proper milligram scale is absolutely essential.
We’re also glad to hear that the shipment finally arrived and that, despite the waiting time, the overall experience was positive. Delivery times can unfortunately be unpredictable, but in most cases the letters do successfully reach their destination.
Thank you again for your patience and for your support — it was a pleasure doing business with you as well.
Please remember that all products sold are Research Chemicals, not intended for human or animal consumption. Proper research safety procedures and a precise scale are required.
ins.worp.6 (verified owner) –
The product met my expectations. It arrived within two weeks of ordering, which is a big plus. Isn’t overly irritating, and the effect doesn’t last too long—which is convenient depending on your schedule, though it might tempt you to repeat the experience. Thanks 🙏
xnjzewdo (verified owner) –
Voluntary subject described the drug as quite pleasant. They described being able to focus and function better, also with some emphasis on temporary relief on anhedonia. As a neutral observer, however, I would not describe the subject as too functional while on the drug (e.g. engaging in activities). Subject did not show any interest in harmful behaviour. Rather surprisingly, they described 2-me-pihp as “not very potent” even on a high dose. That does *not* apply to most people – it should be presumed extremely potent – most likely explanation here is subject’s history of cathinone use as well as antipsychothics.
I stress that professional aid was present with medication specifically appropriate for the subject. I also wish to repeat that the description “not very potent” is almost categorically misleading. Drug should be presumed ultra potent. Subject’s unique history means no generalization can even be hypothesized based on this.