Inleiding:

3-Hydroxyphenazepam is a benzodiazepine derivative known for its hypnotic, sedative, anxiolytic, and anticonvulsant properties. It’s an active metabolite of phenazepam and the prodrug cinazepam.

Chemische eigenschappen:

The compound’s chemical formula is C15H10BrClN2O2, with a molar mass of 365.61 g/mol.

Werkingsmechanisme:

It functions as a positive allosteric modulator at the benzodiazepine site of the GABA A receptor, enhancing the inhibitory effect of the neurotransmitter GABA.

Effects and Uses:

3-Hydroxyphenazepam is known for its calming effects, aiding in anxiety reduction, sedation, and seizure control. Its diminished myorelaxant properties make it unique among benzodiazepines.

Dosering en toediening:

Appropriate dosage varies depending on the condition being treated and individual patient factors. It’s crucial to adhere to prescribed dosages to avoid adverse effects.

Side Effects and Risks:

Common side effects include drowsiness, dizziness, and coordination issues. Prolonged use can lead to dependence and withdrawal symptoms.

Veiligheid en voorzorgsmaatregelen:

Patients with a history of substance abuse or certain medical conditions should use it with caution. Regular monitoring and adherence to guidelines are essential for safe use.

Comparative Analysis:

Compared to phenazepam, 3-Hydroxyphenazepam has a similar efficacy with reduced muscle relaxant effects.

Regulatory Status:

It’s categorized differently across countries, often falling under controlled substances due to its potential for abuse.

Harm Reduction Strategies:

Recommendations include avoiding alcohol, not driving or operating machinery while under its influence, and following a healthcare provider’s advice for tapering off the medication.

Research and Developments:

Ongoing research focuses on understanding its pharmacokinetics, potential therapeutic uses, and risk profile.

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