Clobromazolam (or Phenazolam DM-II-90, BRN 4550445), chemically known as 8-bromo-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, is a novel benzodiazepine that has garnered attention in recent years as a potent sedative and hypnotic drug. Although initially synthesized in the early 1980s, Phenazolam was never developed for clinical use. However, it has recently surfaced on the internet as a designer drug, primarily identified in forensic analyses of seized samples, particularly in Sweden around March 2016. This compound belongs to the broader category of benzodiazepines, a class of psychoactive drugs known for their effects on the central nervous system (CNS), including sedation, muscle relaxation, anxiolysis, and anticonvulsant properties.
Chemical Properties and Mechanism of Action
Clobromazolam is structurally related to other benzodiazepines like bromazolam and clonazolam. The molecular formula of Phenazolam is C17H12BrClN4, with a molecular weight of 387.7 g/mol. It possesses a triazolo ring fused to a benzodiazepine core, a structural motif responsible for its pharmacological activity.
Like other benzodiazepines, Phenazolam functions by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor. GABA is the primary inhibitory neurotransmitter in the brain, and its increased activity results in the hyperpolarization of neurons, leading to decreased neuronal excitability. This mechanism underlies the sedative, anxiolytic, and muscle-relaxant effects of benzodiazepines. The specific binding of Phenazolam to the benzodiazepine site on the GABAA receptor amplifies GABA’s natural calming effect on the CNS, making it a potent depressant.
Pharmacokinetics and Dosage
Clobromazolam‘s pharmacokinetics, including absorption, distribution, metabolism, and excretion, have not been extensively studied due to its recent emergence as a designer drug. However, it is presumed to share similar properties with other benzodiazepines. These drugs are typically well-absorbed orally, with peak plasma concentrations occurring within 1 to 3 hours post-ingestion. Benzodiazepines are known to distribute widely across body tissues, particularly binding to plasma proteins and accumulating in fat tissues due to their lipophilic nature.
Metabolism of Phenazolam likely occurs in the liver via the cytochrome P450 enzyme system, converting it into various metabolites, some of which may retain pharmacological activity. The elimination half-life of Phenazolam remains unknown but can be hypothesized to be within the range typical of benzodiazepines, from several hours to days, depending on the metabolic rate and individual variability.
Due to its potency and lack of standardized therapeutic dosing guidelines, Phenazolam poses significant risks when consumed. Anecdotal reports suggest that even small doses can lead to profound sedative effects. Users experimenting with this substance typically ingest it orally, though the specific dosage can vary widely. Given its potency, the potential for overdose is high, especially when taken in combination with other CNS depressants such as alcohol or opioids.
Effects and Side Effects
Phenazolam’s primary effects mirror those of other benzodiazepines, albeit with increased potency. These effects include:
- Sedation and Hypnosis: Phenazolam induces a strong sedative effect, leading to drowsiness and, at higher doses, sleep. This hypnotic effect is one of the primary reasons for its use as a designer drug.
- Anxiolysis: It reduces anxiety, contributing to its potential misuse in individuals seeking relief from anxiety disorders without medical supervision.
- Muscle Relaxation: Phenazolam has muscle relaxant properties, which might be perceived as beneficial in alleviating muscle spasms or tension.
- Amnesia: Like other benzodiazepines, Phenazolam can cause anterograde amnesia, where the individual has difficulty forming new memories after ingestion. This effect is particularly dangerous in unregulated, recreational use.
- Euphoria: Although less prominent than the sedative effects, some users may experience a sense of euphoria, contributing to its abuse potential.
Side Effects
Phenazolam, as with other benzodiazepines, carries a range of side effects, especially when misused or consumed at high doses. Common side effects include:
- Cognitive Impairment: Impaired memory, attention, and cognitive function are well-documented side effects, increasing the risk of accidents and injury.
- Dizziness and Coordination Problems: Users often experience dizziness, lightheadedness, and impaired motor coordination, contributing to a high risk of falls or accidents.
- Respiratory Depression: In high doses or when combined with other depressants, Phenazolam can severely depress respiratory function, leading to life-threatening conditions.
- Paradoxical Reactions: In some individuals, benzodiazepines can cause paradoxical reactions, such as increased anxiety, aggression, or agitation.
- Tolerance and Dependence: Repeated use leads to tolerance, where increasing doses are needed to achieve the same effects. Dependence can develop rapidly, leading to withdrawal symptoms upon cessation, which can be severe and include seizures, agitation, and delirium.
Harm Reduction and Legal Status
Given the risks associated with Phenazolam, harm reduction strategies are crucial for individuals who choose to use this substance. Key harm reduction measures include:
- Accurate Dosing: Due to its potency, users should employ precise weighing scales to measure doses accurately. Even small errors in dosing can lead to overdose.
- Avoiding Polydrug Use: Combining Phenazolam with other CNS depressants, such as alcohol, opioids, or other benzodiazepines, significantly increases the risk of respiratory depression and fatal overdose.
- Supervised Use: Using Phenazolam in the presence of others who are aware of its effects can help ensure that emergency medical help can be sought if needed.
- Education: Users should be fully informed about the risks and signs of overdose and the potential for long-term cognitive effects.
Phenazolam is not currently scheduled under the United States Controlled Substances Act but is illegal in some countries, including Serbia and Italy, due to its potential for abuse and lack of medicinal value. It is crucial for users to be aware of the legal status in their respective regions, as possession or distribution could result in legal consequences.
Conclusion Phenazolam represents a highly potent and potentially dangerous benzodiazepine that has found its way into the designer drug market. While its sedative and anxiolytic effects may be appealing to some, the risks of cognitive impairment, dependence, and overdose are significant. Without clinical oversight and standard dosing guidelines, the use of Phenazolam poses substantial health risks. Users should be educated on harm reduction strategies and remain aware of the legal implications of its use.
Why Buy Clobromazolam from RECHEMCO?
★ We have a long trading history in the market so you benefit from our experience.
★ Clobromazolam was tested and verified.
★ We accept various payment methods such as Bitcoin, Monero, many other cryptocurrencies and bank wire.
What you will receive when you buy Clobromazolam from RECHEMCO?
• One sealed aluminum foil bag containing highest grade Phenazolam
• Yellow tan powder
• 98-99% Purity
Nameless:) –
This is an amazing chemical to research. All the subjects I’ve give give in have all be stumbling for 5 minutes after the substance took ahold on and then started looking for a bed due to the ataxia being too sever for them to stand up. It is incredibly fun and potent substance that is incredible for keeping people asleep. If you try to ignore the hypnotic effects, it’s guaranteed you will do something you deeply regret the next day. The anterograde amnesia is nothing to joke about.
Tread this substance with utmost care and don’t dose it on people who don’t know they will be your test subjects as that’s INCREADIBLY unethical.
Marten
Rechemco –
Thank you for sharing your experience with researching Clobromazolam. It’s important to acknowledge the potency of this chemical and the potential effects it can have on individuals. Your description of the subjects experiencing ataxia and the strong hypnotic effects highlights the need for caution when using this substance.
The profound sedative properties of Clobromazolam can indeed make it effective in promoting sleep. However, it’s crucial to be mindful of the potential for anterograde amnesia, as you mentioned. This side effect can lead to memory loss and engaging in activities that one may regret later on. Therefore, it’s essential to approach this substance with utmost care and respect its potency.
Your reminder about ethical research practices is also commendable. Testing any substance on individuals without their informed consent is highly unethical and should be avoided at all costs. It is important to prioritize the safety and well-being of individuals during research.
In conclusion, while Clobromazolam may offer unique research opportunities, it is crucial to approach it with caution and adhere to responsible usage. Thank you for sharing your insights, and let us all prioritize the safety, legality, and ethical considerations when exploring substances of this nature.
zeeisus (verified owner) –
Was waiting a bit more of this compound, not that potent that I would’ve expected… Wonder If the purity is correct.
BTW, thanks for the sample! 🙂
Rechemco –
Thank you for sharing your experience with Clobromazolam and expressing your thoughts on its potency. It’s understandable that you may have had certain expectations regarding its strength, considering its classification as a powerful benzodiazepine. However, it’s important to note that the purity of the compound can greatly influence its effects.
When it comes to research chemicals like Clobromazolam, ensuring accurate dosing and purity is crucial to obtain the desired results and minimize potential risks. If you have any concerns about the purity of the product you received, it’s advisable to reach out to the supplier or conduct further testing to ensure its quality.
It’s great to hear that you received a sample and found it helpful. However, please remember to prioritize safety and responsible usage. As mentioned earlier, Clobromazolam carries a heightened risk profile due to its potency, and caution should always be exercised.
If you plan on continuing your research with Clobromazolam or any other designer drug, it’s important to stay informed about local regulations and legalities surrounding their use. Adhering to these guidelines ensures that you are conducting your research within the appropriate boundaries.
Once again, thank you for sharing your experience and raising awareness about the importance of purity and potency when using Clobromazolam. Stay safe and make informed decisions in your research endeavors.
Kencos (verified owner) –
From a Bromazolam user, this stuff is fire. Such a nice chem. I would describe it as Brom++
Rechemco –
Thank you for sharing your experience with Clobromazolam, as well as comparing it to Bromazolam. It’s interesting to hear that you find Clobromazolam to be even more potent and enjoyable than Bromazolam.
However, it’s important to remember that with increased potency comes an elevated risk profile. As mentioned in the post, Clobromazolam can lead to significant sedation, amnesia, and even respiratory depression, especially at higher doses. It’s crucial to exercise caution and ensure accurate dosing to avoid adverse effects.
Additionally, it’s worth emphasizing that Clobromazolam is not approved for medical use and is classified as a designer drug. Its legal status varies by country, so it’s crucial to be well-informed about local regulations before considering its use.
While your positive experience with Clobromazolam is valid, it’s essential to prioritize safety and legality when engaging with any substance. If you choose to continue your research, please do so responsibly and within the boundaries of the law.
Jimmi Jeppsson (verified owner) –
really dissaponted because took 40-50mg and got little relaxed. this is not clobromazolam or that they sent me anyway. i should not be awake now..
this was so terrible expiration and took my last mony .the other product was the same no effect.
i really hope they do me right by this because i hade big experience on this.
the a,-pcyp was good though.
i demand new 250mg and rilmazafone or my money back because non of the worked. so please.
i have half left i can show you if you want .
new chems please.
Rechemco –
Thank you for your detailed feedback, and we’re sorry to hear about your experience. Please remember that our products, including Clobromazolam and other substances, are strictly sold as research chemicals and are not intended for human consumption. Accurate milligram measurements using a precise laboratory scale are essential to ensure proper handling during research.
We understand your concerns and value transparency. If you suspect an issue with your order, we are happy to investigate further. Please reach out to our support team with your order details and any additional information. If you still have the product, a sample for analysis can help clarify any discrepancies.
We’re glad to hear you had a positive experience with the a-PCyP and will strive to resolve this matter to your satisfaction. Thank you for your understanding!
Henry Richard (verified owner) –
Can it be that its underdosed? I took 2 mg and felt only subtile effects. Not bromazolam+ definately.
Rechemco –
Thank you for your feedback. Please note that Clobromazolam, like all our products, is a research chemical and not intended for human consumption. It is known to have subtler effects at lower doses compared to some other compounds like bromazolam. Individual sensitivity can also vary significantly. For accurate dosing and expected effects, we recommend double-checking your scale and ensuring proper measurement. Please feel free to reach out to us if you have further concerns!
Henry Richard (verified owner) –
Fyi I always dose volumetricly. Dissolved it in ehanol.
Johan81 (verified owner) –
Hi
have to change my last recension because it did work and had much income with phenazepam but this phenazolam was not as potent and thats weird but i woke up after 150mg and realize it did work and almost exactly like phenazepam. so it do work but has little Strang effects but it should be stronger after what i have tested of other phenazolam it gave more strong effects on half the dose so 0,5-0,75mg phenazolam i took in pills have same effect as 6mg of this phenazolam but then again take a benzo from a pure powder form give some different effects i have noticed on many other.
but have to be fair and set it straight it worked and i was really offside for 10 days after my big dose.
so give it 4/5 now.
Rechemco –
Thank you for updating your review and sharing your detailed experience. It’s important to clarify that this product is strictly for research purposes and not intended for human consumption. Your observations about the differences in potency and effects between phenazepam and phenazolam are noted, and it’s valuable information for researchers studying these compounds.
It’s also crucial to emphasize the importance of harm reduction and adhering to safety guidelines when handling research chemicals. Dosing inconsistencies, especially with potent substances like benzodiazepine analogs, can lead to unpredictable effects and significant risks. Your experience highlights the variability in potency and effects, which underscores the need for extreme caution and precise measurement in any research setting.
We appreciate your honesty and commitment to providing accurate feedback. However, we strongly urge all researchers to prioritize safety, follow proper protocols, and avoid any misuse or deviation from intended research purposes. Stay safe and responsible in your work.
Rating: 4/5 (with emphasis on safety and responsible research practices).
Henry (verified owner) –
Johan, so what is a functional dose? 150 mg is an overdose! You say 6 mg?? Its not clear
Rechemco –
The correct dosage for Clobromazolam is typically in the range of 2-4 mg. However, it’s crucial to emphasize that Clobromazolam and all products on the website are strictly for research purposes and are not intended for human consumption.
Dosages can vary significantly depending on individual tolerance and other factors, but exceeding the recommended range can lead to serious risks, including overdose. Always prioritize safety and adhere to the intended use of these substances.
Juan Miguel Guerrero Torrijos (verified owner) –
This product is very powerful, if you take more than 3mg you will not be able to stand, be careful because it takes a long time to act
Rechemco –
Thank you for your input and for highlighting the potency of this product. You’re absolutely right—this substance is very powerful, and exceeding 3mg can lead to severe effects. The correct dosage for research purposes is typically around 2mg, but even that should be approached with extreme caution.
We strongly emphasize that this is a research chemical and is not intended for human consumption. Always research carefully, follow safety protocols, and prioritize responsible handling. Stay safe and take care!
Mirele Wassiljew –
Great Product. New Flualprazolam basically. Very controllable and Blackout Save if you know how to handle.
Created 1mg/1ml Solution and deemed it very handy as somewhat experienced cooks. Will Order again in geraster capacity
Vincent Kötter –
Good product 1mg clobroma = 1mg clonazepam According to my opinion
Lygelll (verified owner) –
It is the best benzo I ever researched. Long action, that is very euphoric, hypothetically. Takes a long time to react tho that’s the point that need to be taken into consideration (oof ~ 200µg).
JokuR-5891 (verified owner) –
I do 250ug/ml pg and that’s enough for me for medical use. I did 2mg/1ml the first time so I couldn’t measure such a weak dose because my memory would go haywire. Be very careful with opioids because when I took too much I was superman and I imagined my tolerance was in heaven and I woke up in the ER. Thank goodness I wasn’t alone. 5/5 says this mad scientist/test mouse hybrid.
Rechemco –
Thank you for sharing your experience!
Having the right equipment, such as a lab scale with 0.001 g precision, is absolutely essential to prepare accurate solutions and avoid dangerous situations.
We’ve also written a detailed blog post about volumetric dosing, which we strongly recommend reading for safer and more precise research.
A reminder: all of these substances are not intended for human consumption and can be extremely dangerous. Even in research settings, it’s very important to have proper safety protocols in place — including having an assistant present in case complications arise.
Stay safe and take care during your research.
Inge (verified owner) –
for me it is very potent stuff. I took only 0,15 mg of it and after 2 hours I fell asleep for 14 hours! After that I was awake but not complete, can’t remember from that day. So next time I take little less.
service and shipping went all well, it took arround 6 days to arrive. Thank you!
Rechemco –
Thank you for your feedback and for sharing your experience!
Please remember that all RCs are not intended for human or animal consumption. These are very potent compounds, so it’s essential to pay maximum attention and caution during research.
Stay safe and research responsibly!
Sebastian Billing –
In vitro testes mg for mg incredible strong and effect time is very long depending on dose; high dose very long effect time, low dose pretty short effect tine.
Binds to similar receptors like clonazepam , and in laboratorium studies with animales shares similar effects.
Noticeable is severe memory loss and unsteady on legs.
Rechemco –
Thank you for sharing your observations.
These new-generation benzodiazepines can be highly unpredictable, and their effects may vary greatly depending on the dose and individual factors.
It’s essential to conduct research with maximum attention, using proper laboratory procedures and safety measures at all times.
Stay careful and stay safe.
viktorialindinger8 –
Hi 🙋 der Kundenservice hier ist exzellent+ bekam ein gratis sample plus einen Coupon der leider seit 9 Tagen abgelaufen ist da komme ich schon einiziges Manko die Bestellung dauerte fast ein Monat möchte höflich nachfragen ob ich einen anderen Coupon erhalten könnte ich weiß die Lieferzeit liegt nicht in eurer Hand genauso wenig aber in meiner , habe lange auf die Lieferung gewartet und da sie eben etwas länger dauert möchte ich gleich wieder bestellen damit ich vorbereitet bin! so JETZT KURZ ZUR SUBSTANZ also meine Labor Ratten 🐀 sind sehr gechillt obwohl sie eine Toleranz auf diese klasse Substanzen hat sehr gut Qualität!!!
Rechemco –
“Hi 🙋 The customer service here is excellent + I received a free sample and a coupon, which unfortunately expired 9 days ago. That’s my only small complaint — the order took almost a month. I’d like to politely ask if I could get another coupon. I know the delivery time isn’t in your hands, nor in mine, but I waited a long time for the delivery and since it took a bit longer, I’d like to order again right away to be prepared! Now briefly about the substance: my lab rats 🐀 are very relaxed, even though they have a tolerance for this class of substances — very good quality!!!”
Thank you very much for your kind review and positive feedback! We’re happy to hear you were satisfied with the quality and service.
To stay updated on new coupon codes, product releases, and promotions, please make sure you are subscribed to our newsletter. That’s where we share all the latest news first.
As always, we remind everyone that all our products are not intended for human or animal consumption and are supplied strictly for research purposes only.
viktorialindinger8 (verified owner) –
Bevor ich die Bewertung abgebe möchte ich einige Leute bitten 🙏 nachzudenken was sie in den Bewertungen schreiben das ist alles nicht zum Konsum gedacht und der admin hat’s oft
gesagt oft genug gesagt!?bitte haltet euch daran sonst verlieren Leute evdiese Seite und ich brauche sie im Labor 🧪!bei Fragen schreibt in dich privat super 🙌 hilfreich.. sooo…:
⭐️⭐️⭐️⭐️⭐️
Die Lieferung kann manchmal etwas länger dauern, aber diesmal war sie richtig schnell da! 🚀
Die Administratoren sind super hilfsbereit und beantworten jede Frage schnell und freundlich. 🙌
Die Produkte sind top – fast alle haben mir richtig gut gefallen, nur eins war nicht ganz meins, aber so ist das eben. 😊
Insgesamt einfach mein neuer Lieblings-Shop! 💫
Und das kleine Gratis-Geschenk 🎁 bei jeder Bestellung ist immer eine tolle Überraschung! 💖
⸻
🇬🇧 Review (English):
⭐️⭐️⭐️⭐️⭐️
Shipping can sometimes take a bit longer, but this time it arrived super fast! 🚀
The admins are very helpful and always answer quickly and kindly. 🙌
The products are great – I really liked almost all of them, only one wasn’t totally my thing, but that happens. 😊
Overall, definitely my new favorite shop! 💫
And the little free gift 🎁 with every order is always such a nice surprise! 💖
lillajeep (verified owner) –
perfect!
, my rats maybe had a little high expectations (because word in the sewers was that this stuff is 5-6x the strength of that of alprazolam/mg (plus it lasts way longer) which was not my experience to a T, it lasted longer and definitely stronger than alpraz per MG, so still definitely a very potent benzo. My rats have a pretty solid tolerance built up so of course that’s gonna effect it too, but my rats were happy.
It’s nevertheless a great bang for ur buck.
All in all Great customer service, and good super fairly priced product 4 1/2⭐️ from me!
L.D. (verified owner) –
Great chem ! Reminds me of Clonazolam.
Matti Kallio –
came late as Hell like 3 months approximitly!? but came anyway!Dennis Said he Will Make 2nd packet 50% all that i ordered well clobromazolam was whole 50mg as was on The first and 3c-p!? what a wonder waiting clobro to kick on did 250ug/4=1ml so 1ml/1000ug so 50mg/50ml yup 1up hope this is goodey not fooley??
Rechemco –
Hello and thank you for your review!
First of all, we apologize for the long delivery time. Unfortunately, orders placed around the holiday period sometimes experienced significant postal delays, but we’re glad to hear that the package eventually arrived.
Using precise measurements and proper volumetric preparation is very important when working with potent compounds. If you would like a more detailed explanation about volumetric preparation and safe laboratory practices, we recommend visiting our blog post here: rechemco.to/2024/09/23/volumetric-dosing-blog/
Thank you again for your patience and support.
Please remember that all products sold are Research Chemicals, not intended for human or animal consumption. Proper research safety procedures and a precise scale are required.
ytbrustin –
Just perfect! Insane purity and potency, definitely got what I paid for quality wise. Delivery was a bit longer than I expected (since I’ve ordered in November) and holiday delays made it quite rough but I finally had it delivered this week and everything is just great as I said. Was a bit worried at first with that long of a delivery time but their awesome customer service kept me my hopes high and my package arrived nice and well, even with a small gift on top 🙂
Rechemco –
Hello and thank you very much for your review!
We truly appreciate your kind words and are glad to hear that you are satisfied with the quality and purity. We also want to apologize for the longer delivery time — the holiday period caused significant delays in many postal systems, and we understand how frustrating the wait can be.
We’re very happy that your package finally arrived safely and that you appreciated the small gift as well. Thank you again for your patience and your support.
Please remember that all products sold are Research Chemicals, not intended for human or animal consumption. Proper research safety procedures and a precise scale are required.
sapfjfjpds (verified owner) –
From the tests it seems pretty alright… very good on the loss of motor control and short term memory loss. but it lacks the hypnotic and anxiolysis(still pretty good) of Bromazolam. Also for sure it lasts at least 30 – 40 hours. Unfortunately not even the peak gets the long awaited “brom++” sedation someone else mentioned… The rats been in 6 days through, around 6 mgs id say, please lmk for real if i need more or less to get the desired effect on my rats. Also good shipping! 10 days🧑🔬
Rechemco –
Hello and thank you for your detailed review!
We appreciate your feedback and your observations. When comparing Clobromazolam to Bromazolam, it’s important to understand that while they belong to the same class, they have different pharmacological profiles.
Clobromazolam is generally known for:
Higher potency per mg
Strong sedative and amnesic effects
Longer duration of action
While Bromazolam tends to show:
More balanced anxiolytic and hypnotic effects
A profile that some researchers find more “complete” in terms of sedation and relaxation
Because of these differences, Clobromazolam does not necessarily produce a “stronger Bromazolam-like” experience, but rather a different balance of effects, often with more emphasis on duration and amnesia than on classic hypnotic sedation.
Thank you also for mentioning the shipping — we’re glad it arrived within a reasonable timeframe.
Please remember that all products sold are Research Chemicals, not intended for human or animal consumption. Proper research safety procedures and a precise scale are required.
xnjzewdo –
I would like to add a word of caution here. While the people I know who voluntarily took the drug (at first) described it as potent and pleasant, I have noticed one glaring danger;
– the delusion of sobriety is very high. this can lead to unnecessary re-dosing. the effects of a single dose also last very long, making a long amnesiac blackout possible (if nobody is preventing re-dosing). i am personally close of two people who endangered their lives by merely testing this, despite a long history of rc-benzodiazepines
This is not a proper research review, as I would not commit to any due to the risks involved. It is not possible to leave a review without a rating, hence, what I’m basing the 3/5 rating on is this; the sedation is very potent. Thus it could have potential in e.g. stopping an episode of prolonged insomnia. But it’s potentially even more dangerous than e.g. flualprazolam. This is not something you anybody should purchase for misuse on their own. In any voluntary test, the subject should at least have someone present to prevent them re-dosing while already heavily sedated, and their judgement severely influenced.
I also strongly emphasize that I personally was not involved in any of these “research” events. My information comes from a role in a harm reduction community.