SR-17018 CN Export – Wholesale

200 - 2750

SR-17018: Innovative Pain Relief with Reduced Side Effects

SR-17018 is a groundbreaking μ-opioid receptor agonist designed to provide effective pain relief while minimizing common opioid-related side effects.

  • G Protein-Biased Signaling: Targets pain pathways with reduced activation of β-arrestin 2, potentially lowering risks of respiratory depression and tolerance.
  • Enhanced Safety Profile: Demonstrates fewer adverse effects in preclinical studies compared to traditional opioids.
  • Effective Analgesia: Provides potent pain relief in various animal models, including neuropathic pain scenarios.
  • Oral Bioavailability: Suitable for oral administration, offering convenience and compliance.

Experience a new era of pain management with SR-17018, combining efficacy and safety in one innovative compound.

SR-17018 está pronto para ser enviado em 48h-72h após o pagamento.

Prazo médio de entrega: 1 mês.

Todas as drogas de marca vendidas neste sítio Web destinam-se à investigação e a aplicações forenses.

ATENÇÃO!
IN CASE OF LOSS, WRONG ADDRESS OR ANY OTHER ISSUE, FOR THIS PRODUCT IS NOT ALLOWED ANY RESHIP NOR REFUND

 

SR-17018 is a novel small-molecule agonist targeting the μ-opioid receptor (MOR), exhibiting a pronounced bias towards G protein signaling over β-arrestin 2 recruitment. This pharmacological profile aims to retain potent analgesic effects while mitigating common opioid-induced adverse effects such as respiratory depression, tolerance, and dependence.

Pharmacodynamics and Mechanism of Action

SR-17018’s unique action stems from its selective activation of G protein pathways associated with MOR, minimizing β-arrestin 2-mediated signaling. This bias is believed to underlie its reduced propensity for inducing respiratory depression and other side effects commonly associated with traditional opioids.

Farmacocinética

  • Absorção: SR-17018 demonstrates good oral bioavailability.
  • Distribuição: It effectively crosses the blood-brain barrier, ensuring central nervous system activity.
  • Metabolismo: The compound undergoes hepatic metabolism, primarily via cytochrome P450 enzymes.
  • Elimination: SR-17018 has a half-life of approximately 6 hours, supporting twice-daily dosing regimens.

Efficacy in Preclinical Models

In various animal models, SR-17018 has shown:

  • Potent antinociceptive effects comparable to morphine.
  • Sustained efficacy upon repeated administration, indicating a lower tendency for tolerance development.
  • Effectiveness in neuropathic pain models, such as paclitaxel-induced allodynia.

Safety Profile

Compared to traditional opioids, SR-17018 exhibits:

  • Reduced respiratory depression.
  • Lower incidence of constipation.
  • Minimal development of physical dependence.

Dosagem e administração

In preclinical studies, SR-17018 has been administered orally at doses ranging from 1 to 48 mg/kg, with 24 mg/kg/day being effective for sustained analgesia. However, optimal dosing in humans remains to be established through clinical trials.

Potential Side Effects

While SR-17018 shows a favorable safety profile, potential side effects observed in animal studies include:

  • Mild sedation.
  • Gastrointestinal disturbances at higher doses.

Harm Reduction Considerations

SR-17018’s pharmacological characteristics suggest a lower abuse potential. Nonetheless, harm reduction strategies, including patient education and monitoring, remain essential to mitigate risks associated with opioid therapy.

Conclusão

SR-17018 represents a promising advancement in opioid pharmacotherapy, offering potent analgesia with a reduced side effect burden. Ongoing research is necessary to fully elucidate its clinical potential and safety in human populations.

Note: SR-17018 is currently under preclinical investigation. Clinical efficacy and safety in humans have yet to be established.


Porquê comprar SR-17018 da RECHEMCO?

Temos uma longa história de negociação no mercado, pelo que beneficia da nossa experiência.
★ SR-14968 foi testado e verificado.
Aceitamos vários métodos de pagamento, como Bitcoin, Monero e transferência bancária.

O que recebe quando compra SR-17018 da RECHEMCO?

- Um saco de folha de alumínio selado com um produto da mais alta qualidade SR-17018
• crystalline powder
• 99% Purity

Quantidade

5g, 10g, 25g, 50g, 100g, 250g

1 avaliação de SR-17018 CN Export – Wholesale

  1. dpjoselu (proprietário verificado) -

    Very fast shipping, 7 days. Perfect quality. You are very professional. Very well protected and packed shipping.

    • Rechemco -

      Thank you so much for your kind feedback! We are glad you’re happy with the quality and packaging of your order. Ensuring safe delivery and professional service is our top priority. We truly appreciate your support!

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