Clobromazolam (or Phenazolam DM-II-90, BRN 4550445), chemically known as 8-bromo-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, is a novel benzodiazepine that has garnered attention in recent years as a potent sedative and hypnotic drug. Although initially synthesized in the early 1980s, Phenazolam was never developed for clinical use. However, it has recently surfaced on the internet as a designer drug, primarily identified in forensic analyses of seized samples, particularly in Sweden around March 2016. This compound belongs to the broader category of benzodiazepines, a class of psychoactive drugs known for their effects on the central nervous system (CNS), including sedation, muscle relaxation, anxiolysis, and anticonvulsant properties.
Chemical Properties and Mechanism of Action
Clobromazolam is structurally related to other benzodiazepines like bromazolam and clonazolam. The molecular formula of Phenazolam is C17H12BrClN4, with a molecular weight of 387.7 g/mol. It possesses a triazolo ring fused to a benzodiazepine core, a structural motif responsible for its pharmacological activity.
Like other benzodiazepines, Phenazolam functions by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor. GABA is the primary inhibitory neurotransmitter in the brain, and its increased activity results in the hyperpolarization of neurons, leading to decreased neuronal excitability. This mechanism underlies the sedative, anxiolytic, and muscle-relaxant effects of benzodiazepines. The specific binding of Phenazolam to the benzodiazepine site on the GABAA receptor amplifies GABA’s natural calming effect on the CNS, making it a potent depressant.
Pharmacokinetics and Dosage
Clobromazolam‘s pharmacokinetics, including absorption, distribution, metabolism, and excretion, have not been extensively studied due to its recent emergence as a designer drug. However, it is presumed to share similar properties with other benzodiazepines. These drugs are typically well-absorbed orally, with peak plasma concentrations occurring within 1 to 3 hours post-ingestion. Benzodiazepines are known to distribute widely across body tissues, particularly binding to plasma proteins and accumulating in fat tissues due to their lipophilic nature.
Metabolism of Phenazolam likely occurs in the liver via the cytochrome P450 enzyme system, converting it into various metabolites, some of which may retain pharmacological activity. The elimination half-life of Phenazolam remains unknown but can be hypothesized to be within the range typical of benzodiazepines, from several hours to days, depending on the metabolic rate and individual variability.
Due to its potency and lack of standardized therapeutic dosing guidelines, Phenazolam poses significant risks when consumed. Anecdotal reports suggest that even small doses can lead to profound sedative effects. Users experimenting with this substance typically ingest it orally, though the specific dosage can vary widely. Given its potency, the potential for overdose is high, especially when taken in combination with other CNS depressants such as alcohol or opioids.
Effects and Side Effects
Phenazolam’s primary effects mirror those of other benzodiazepines, albeit with increased potency. These effects include:
- Sedation and Hypnosis: Phenazolam induces a strong sedative effect, leading to drowsiness and, at higher doses, sleep. This hypnotic effect is one of the primary reasons for its use as a designer drug.
- Anxiolysis: It reduces anxiety, contributing to its potential misuse in individuals seeking relief from anxiety disorders without medical supervision.
- Rilassamento muscolare: Phenazolam has muscle relaxant properties, which might be perceived as beneficial in alleviating muscle spasms or tension.
- Amnesia: Like other benzodiazepines, Phenazolam can cause anterograde amnesia, where the individual has difficulty forming new memories after ingestion. This effect is particularly dangerous in unregulated, recreational use.
- Euphoria: Although less prominent than the sedative effects, some users may experience a sense of euphoria, contributing to its abuse potential.
Effetti collaterali
Phenazolam, as with other benzodiazepines, carries a range of side effects, especially when misused or consumed at high doses. Common side effects include:
- Cognitive Impairment: Impaired memory, attention, and cognitive function are well-documented side effects, increasing the risk of accidents and injury.
- Dizziness and Coordination Problems: Users often experience dizziness, lightheadedness, and impaired motor coordination, contributing to a high risk of falls or accidents.
- Respiratory Depression: In high doses or when combined with other depressants, Phenazolam can severely depress respiratory function, leading to life-threatening conditions.
- Paradoxical Reactions: In some individuals, benzodiazepines can cause paradoxical reactions, such as increased anxiety, aggression, or agitation.
- Tolleranza e dipendenza: Repeated use leads to tolerance, where increasing doses are needed to achieve the same effects. Dependence can develop rapidly, leading to withdrawal symptoms upon cessation, which can be severe and include seizures, agitation, and delirium.
Harm Reduction and Legal Status
Given the risks associated with Phenazolam, harm reduction strategies are crucial for individuals who choose to use this substance. Key harm reduction measures include:
- Accurate Dosing: Due to its potency, users should employ precise weighing scales to measure doses accurately. Even small errors in dosing can lead to overdose.
- Avoiding Polydrug Use: Combining Phenazolam with other CNS depressants, such as alcohol, opioids, or other benzodiazepines, significantly increases the risk of respiratory depression and fatal overdose.
- Supervised Use: Using Phenazolam in the presence of others who are aware of its effects can help ensure that emergency medical help can be sought if needed.
- Education: Users should be fully informed about the risks and signs of overdose and the potential for long-term cognitive effects.
Phenazolam is not currently scheduled under the United States Controlled Substances Act but is illegal in some countries, including Serbia and Italy, due to its potential for abuse and lack of medicinal value. It is crucial for users to be aware of the legal status in their respective regions, as possession or distribution could result in legal consequences.
Conclusione Phenazolam represents a highly potent and potentially dangerous benzodiazepine that has found its way into the designer drug market. While its sedative and anxiolytic effects may be appealing to some, the risks of cognitive impairment, dependence, and overdose are significant. Without clinical oversight and standard dosing guidelines, the use of Phenazolam poses substantial health risks. Users should be educated on harm reduction strategies and remain aware of the legal implications of its use.
Perché acquistare Clobromazolam da RECHEMCO?
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Cosa riceverete con l'acquisto Clobromazolam da RECHEMCO?
- Un sacchetto sigillato in foglio di alluminio contenente il massimo livello di qualità. Phenazolam
• Yellow tan powder
• 98-99% Purity
Nameless:) -
This is an amazing chemical to research. All the subjects I’ve give give in have all be stumbling for 5 minutes after the substance took ahold on and then started looking for a bed due to the ataxia being too sever for them to stand up. It is incredibly fun and potent substance that is incredible for keeping people asleep. If you try to ignore the hypnotic effects, it’s guaranteed you will do something you deeply regret the next day. The anterograde amnesia is nothing to joke about.
Tread this substance with utmost care and don’t dose it on people who don’t know they will be your test subjects as that’s INCREADIBLY unethical.
Marten
Rechemco -
Thank you for sharing your experience with researching Clobromazolam. It’s important to acknowledge the potency of this chemical and the potential effects it can have on individuals. Your description of the subjects experiencing ataxia and the strong hypnotic effects highlights the need for caution when using this substance.
The profound sedative properties of Clobromazolam can indeed make it effective in promoting sleep. However, it’s crucial to be mindful of the potential for anterograde amnesia, as you mentioned. This side effect can lead to memory loss and engaging in activities that one may regret later on. Therefore, it’s essential to approach this substance with utmost care and respect its potency.
Your reminder about ethical research practices is also commendable. Testing any substance on individuals without their informed consent is highly unethical and should be avoided at all costs. It is important to prioritize the safety and well-being of individuals during research.
In conclusion, while Clobromazolam may offer unique research opportunities, it is crucial to approach it with caution and adhere to responsible usage. Thank you for sharing your insights, and let us all prioritize the safety, legality, and ethical considerations when exploring substances of this nature.
zeeisus (proprietario verificato) -
Was waiting a bit more of this compound, not that potent that I would’ve expected… Wonder If the purity is correct.
BTW, thanks for the sample! 🙂
Rechemco -
Thank you for sharing your experience with Clobromazolam and expressing your thoughts on its potency. It’s understandable that you may have had certain expectations regarding its strength, considering its classification as a powerful benzodiazepine. However, it’s important to note that the purity of the compound can greatly influence its effects.
When it comes to research chemicals like Clobromazolam, ensuring accurate dosing and purity is crucial to obtain the desired results and minimize potential risks. If you have any concerns about the purity of the product you received, it’s advisable to reach out to the supplier or conduct further testing to ensure its quality.
It’s great to hear that you received a sample and found it helpful. However, please remember to prioritize safety and responsible usage. As mentioned earlier, Clobromazolam carries a heightened risk profile due to its potency, and caution should always be exercised.
If you plan on continuing your research with Clobromazolam or any other designer drug, it’s important to stay informed about local regulations and legalities surrounding their use. Adhering to these guidelines ensures that you are conducting your research within the appropriate boundaries.
Once again, thank you for sharing your experience and raising awareness about the importance of purity and potency when using Clobromazolam. Stay safe and make informed decisions in your research endeavors.
Kencos (proprietario verificato) -
From a Bromazolam user, this stuff is fire. Such a nice chem. I would describe it as Brom++
Rechemco -
Thank you for sharing your experience with Clobromazolam, as well as comparing it to Bromazolam. It’s interesting to hear that you find Clobromazolam to be even more potent and enjoyable than Bromazolam.
However, it’s important to remember that with increased potency comes an elevated risk profile. As mentioned in the post, Clobromazolam can lead to significant sedation, amnesia, and even respiratory depression, especially at higher doses. It’s crucial to exercise caution and ensure accurate dosing to avoid adverse effects.
Additionally, it’s worth emphasizing that Clobromazolam is not approved for medical use and is classified as a designer drug. Its legal status varies by country, so it’s crucial to be well-informed about local regulations before considering its use.
While your positive experience with Clobromazolam is valid, it’s essential to prioritize safety and legality when engaging with any substance. If you choose to continue your research, please do so responsibly and within the boundaries of the law.
Jimmi Jeppsson (proprietario verificato) -
really dissaponted because took 40-50mg and got little relaxed. this is not clobromazolam or that they sent me anyway. i should not be awake now..
this was so terrible expiration and took my last mony .the other product was the same no effect.
i really hope they do me right by this because i hade big experience on this.
the a,-pcyp was good though.
i demand new 250mg and rilmazafone or my money back because non of the worked. so please.
i have half left i can show you if you want .
new chems please.
Rechemco -
Thank you for your detailed feedback, and we’re sorry to hear about your experience. Please remember that our products, including Clobromazolam and other substances, are strictly sold as research chemicals and are not intended for human consumption. Accurate milligram measurements using a precise laboratory scale are essential to ensure proper handling during research.
We understand your concerns and value transparency. If you suspect an issue with your order, we are happy to investigate further. Please reach out to our support team with your order details and any additional information. If you still have the product, a sample for analysis can help clarify any discrepancies.
We’re glad to hear you had a positive experience with the a-PCyP and will strive to resolve this matter to your satisfaction. Thank you for your understanding!
Henry Richard (proprietario verificato) -
Can it be that its underdosed? I took 2 mg and felt only subtile effects. Not bromazolam+ definately.
Rechemco -
Thank you for your feedback. Please note that Clobromazolam, like all our products, is a research chemical and not intended for human consumption. It is known to have subtler effects at lower doses compared to some other compounds like bromazolam. Individual sensitivity can also vary significantly. For accurate dosing and expected effects, we recommend double-checking your scale and ensuring proper measurement. Please feel free to reach out to us if you have further concerns!
Henry Richard (proprietario verificato) -
Fyi I always dose volumetricly. Dissolved it in ehanol.
Johan81 (proprietario verificato) -
Hi
have to change my last recension because it did work and had much income with phenazepam but this phenazolam was not as potent and thats weird but i woke up after 150mg and realize it did work and almost exactly like phenazepam. so it do work but has little Strang effects but it should be stronger after what i have tested of other phenazolam it gave more strong effects on half the dose so 0,5-0,75mg phenazolam i took in pills have same effect as 6mg of this phenazolam but then again take a benzo from a pure powder form give some different effects i have noticed on many other.
but have to be fair and set it straight it worked and i was really offside for 10 days after my big dose.
so give it 4/5 now.
Rechemco -
Thank you for updating your review and sharing your detailed experience. It’s important to clarify that this product is strictly for research purposes and not intended for human consumption. Your observations about the differences in potency and effects between phenazepam and phenazolam are noted, and it’s valuable information for researchers studying these compounds.
It’s also crucial to emphasize the importance of harm reduction and adhering to safety guidelines when handling research chemicals. Dosing inconsistencies, especially with potent substances like benzodiazepine analogs, can lead to unpredictable effects and significant risks. Your experience highlights the variability in potency and effects, which underscores the need for extreme caution and precise measurement in any research setting.
We appreciate your honesty and commitment to providing accurate feedback. However, we strongly urge all researchers to prioritize safety, follow proper protocols, and avoid any misuse or deviation from intended research purposes. Stay safe and responsible in your work.
Rating: 4/5 (with emphasis on safety and responsible research practices).
Henry (proprietario verificato) -
Johan, so what is a functional dose? 150 mg is an overdose! You say 6 mg?? Its not clear
Rechemco -
The correct dosage for Clobromazolam is typically in the range of 2-4 mg. However, it’s crucial to emphasize that Clobromazolam and all products on the website are strictly for research purposes and are not intended for human consumption.
Dosages can vary significantly depending on individual tolerance and other factors, but exceeding the recommended range can lead to serious risks, including overdose. Always prioritize safety and adhere to the intended use of these substances.
Juan Miguel Guerrero Torrijos (proprietario verificato) -
This product is very powerful, if you take more than 3mg you will not be able to stand, be careful because it takes a long time to act
Rechemco -
Thank you for your input and for highlighting the potency of this product. You’re absolutely right—this substance is very powerful, and exceeding 3mg can lead to severe effects. The correct dosage for research purposes is typically around 2mg, but even that should be approached with extreme caution.
We strongly emphasize that this is a research chemical and is not intended for human consumption. Always research carefully, follow safety protocols, and prioritize responsible handling. Stay safe and take care!