Fluoprazolam – Benzimidazodiazepina Substituída por Piperazinil
🧬 Visão geral
Fluoprazolam é um potente sintético benzimidazo[1,2-a][1,4]diazepina derivado, estruturalmente distinto tanto do alprazolam quanto do flualprazolam. Ele incorpora:
- A 2-fluorofenil substituição
- Um grupo 8-nitro no núcleo benzimidazo
- A 4-metilpiperazin-1-ilmetileno porção na posição 2
Este padrão de substituição único é projetado para modular afinidade do receptor GABAA ao mesmo tempo que altera propriedades físico-químicas como lipofilicidade, penetração no SNC e estabilidade metabólica.
⚛️ Identidade Química
- Nome IUPAC: (Z)-6-(2-fluorofenil)-2-((4-metilpiperazin-1-il)metileno)-8-nitro-4H-benzo[f]imidazo[1,2-a][1,4]diazepin-1-ona
- Fórmula Molecular: C₂₂H₂₁FN₆O₃
- Peso molecular: ~448.46 g/mol
- Classe Química: Benzimidazo[1,2-a][1,4]diazepina (nitro-substituída)
⚙️ Farmacologia
Como um ligante da classe das benzodiazepinas, presume-se que o Fluoprazolam atue como um modulador alostérico positivo no sítio benzodiazepínico do receptor GABAA. A ligação potencializa o efeito do GABA endógeno, aumentando o influxo neuronal de cloreto, levando a:
- Efeitos sedativo-hipnóticos
- Ansiólise
- Atividade anticonvulsivante
- Relaxamento muscular
O piperazinilmetileno A cadeia lateral pode alterar a seletividade do subtipo de receptor ou conferir mudanças farmacocinéticas adicionais (ex., metabolismo mais lento).
O nitro grupo em análogos de benzodiazepínicos está frequentemente associado a uma meia-vida mais longa e alta afinidade pelo receptor.
📈 Farmacocinética (com base em dados de classe, estudos específicos sobre Fluoprazolam limitados)
- Início: Provavelmente dentro de 30–60 minutos (oral)
- Duração: Estimada em 8–14 horas (possível sedação residual)
- Metabolismo: Hepático, provável envolvimento do CYP3A4
- Excreção: Metabólitos urinários após transformações oxidativas e redutivas
⚠️ Efeitos e Riscos
Efeitos desejados potenciais (em doses controladas de pesquisa):
- Sedação profunda
- Ansiedade reduzida
- Ação anticonvulsivante
- Indução do sono
Efeitos adversos / sintomas de overdose:
- Depressão respiratória
- Incoordenação motora grave
- Apagões de memória
- Hipotensão
- Inconsciência prolongada
Dada a provável alta potência, quantidades ativas sub-miligrama são plausíveis, exigindo extremo cuidado na medição e manuseio.
❗ Redução de Danos para Uso em Laboratório
- Sempre pese com balanças analíticas de 0,1 mg ou usar diluição volumétrica
- Evite inalação/exposição dérmica — use EPI e capela
- Armazenar com segurança para evitar acesso não autorizado
- Manter longe do calor, luz e umidade
🔬 Aplicações de Pesquisa
O incomum do Fluoprazolam piperazinilmetileno substituição torna-o uma referência valiosa para:
- Estudos de relação estrutura-atividade (SAR) dentro das benzodiazepinas
- Modelagem farmacocinética dos efeitos de cadeias laterais volumosas
- Padrão forense para testes analíticos de amostras apreendidas
🌍 Situação legal
Embora o agendamento específico varie, a maioria das jurisdições controla as nitrobenzodiazepinas sob leis de substâncias psicotrópicas ou disposições análogas.
Os pesquisadores devem confirmar Legalidade local antes da aquisição ou manuseio.
📌 Resumo
Fluoprazolam é um benzimidazodiazepínico de alta afinidade com uma estrutura distinta, provavelmente efeitos depressores do SNC potentes e longa duração. Seu perfil o torna importante em toxicologia forense e pesquisa sobre receptores de benzodiazepina, mas também exige protocolos de segurança rigorosos.
Porquê comprar Fluoprazolam da RECHEMCO?
Temos uma longa história de negociação no mercado, pelo que beneficia da nossa experiência.
★ Fluoprazolam foi testado e verificado.
★ Aceitamos vários métodos de pagamento, como Bitcoin, as principais criptomoedas, cartão de crédito via Plisio e transferência bancária.
O que recebe quando compra Fluoprazolam da RECHEMCO?
- Um saco de folha de alumínio selado com um produto da mais alta qualidade Fluoprazolam
• white/yellowish powder
• 99% Purity
Bernard victor -
Thanks for this benzo !!!
experimenter (proprietário verificado) -
Better than expected, very fun benzo with a lot of sedative potential, with a small amount you sleep all night
Colony (proprietário verificado) -
It’s fine. No complaints, except for the potency (or lack thereof).
Rechemco -
Olá e obrigado pela sua avaliação!
We appreciate your feedback and are glad to hear that everything else was fine. Please keep in mind that different research chemicals can vary significantly in dosage, potency, and effects — some are naturally stronger or more active at lower quantities than others. We always recommend comparing the specific compound’s data and adjusting your research parameters accordingly.
Por favor, lembre-se de que todos os produtos vendidos são produtos químicos de pesquisa, não destinados ao consumo humano ou animal. Procedimentos adequados de segurança em pesquisa e uma balança precisa são necessários.
Nicholai Hansen (proprietário verificado) -
Can’t tell you how happy I am, that rechem is a solid provider for labs! We’re excited to meet professionals once again, very good quality and predictable shipping times!
viktorialindinger8 (proprietário verificado) -
⭐️⭐️⭐️⭐️⭐️
A entrega às vezes pode demorar um pouco mais, mas desta vez foi super rápida! 🚀
Os administradores são super prestativos e respondem a todas as perguntas de forma rápida e amigável. 🙌
Produkte top – wirklich sehr gute Qualität! 👍
Und jedes Mal liegt ein kleines Gratis-Geschenk dabei 🎁 – das macht das Ganze noch sympathischer!
⸻
🇬🇧 English):
⭐️⭐️⭐️⭐️⭐️
Shipping can sometimes take a little longer, but this time it arrived really fast! 🚀
The admins are very helpful and always answer questions quickly and kindly. 🙌
Products are excellent – really great quality! 👍
And there’s always a small free gift included 🎁 – such a nice and thoughtful touch! 💫
jeppssonjimmi46 (proprietário verificado) -
tested 4mg because have thats what many say you need to get good effect and i did that (4mg) was the sweetspot 👌
waited 40min to start feel then 10-15min more for full effect and i loved this one.
i have seen that they that sell pressed pills of this also do them at 4mg but i think 2mg is enough if its only some relaxing effect you need or research..
but it was better then i have Read about it..
giving only 4/5 because you need 4-6mg for good effects.
you must start dose youre blotters 2mg at least.
Thanks ♥️
viktorialindinger8 (proprietário verificado) -
Order arrived quickly this time 🕰️ this was my first Fluoprazolam – good but my favourite is still Clobromazolam in lobority really interesting substance and arrived me twice and can say the quality is stable very good! Best RC shop – new favourite one! New order was made today thanks 🙏 team !
Mrsss (proprietário verificado) -
Like it, thanks for that perfect service. it takes a little bit longer but thats fine, all came trough thank you for that service order only here. 🙂 Fluoprazolam is rly not bad. And thank you for the sample always i rly thank you for that. Next order will be make soon!! :))
Rechemco -
Olá e obrigado pela sua avaliação!
We really appreciate your support and your positive words about our service. The postal system can sometimes be unpredictable, but as you noticed, the packages always make it through in the end.
Fluoprazolam is indeed a very promising chemical, and we’re glad to hear your research went well. Thank you also for your kind words about the samples — we’re happy you enjoy them. Looking forward to your next order!
Por favor, lembre-se de que todos os produtos vendidos são Produtos Químicos de Pesquisa, não destinados ao consumo humano ou animal. Procedimentos adequados de segurança de pesquisa e uma balança precisa são necessários.
katkom35 (proprietário verificado) -
Eu pedi 1g de fluoprazolam, mas recebi apenas 50 mg; além disso, as etiquetas estavam trocadas no pacote com blotters que provavelmente recebi como brinde, dizia fluoprazolam freebase 1g e na embalagem do pó em si estava marcado como fluoprazolam blotters 0.5. Sinto-me decepcionado.
Rechemco -
Hello and thank you for your message.
We understand your concern, and we are here to clarify the situation.
Fluoprazolam is available in two formats:
Raw powder (sold by weight)
Blotters at 0.5 mg each
In your case, the labels indicate that you received both formats, and the confusion comes from the way the blotter label is written. The note “0.5” refers to 0.5 mg per blotter, not 0.5 g of powder. It seems the label was misinterpreted rather than the wrong product being sent.
If you would like, you can send us a photo of the items and labels so we can confirm everything for you and ensure full clarity.
Por favor, lembre-se de que todos os produtos vendidos são Produtos Químicos de Pesquisa, não destinados ao consumo humano ou animal. Procedimentos adequados de segurança de pesquisa e uma balança precisa são necessários.
katkom35 (proprietário verificado) -
Ah, então foram apenas os nomes nas etiquetas das sacolas que se misturaram. Mas isso me confundiu muito, por favor tenha cuidado com isso.
Rechemco -
Correct.
Tomi Haapaniemi (proprietário verificado) -
Helps with sleep, no extreme hangover in the animaltests made so far.
Due to substiutions as nitro, imidazo- piperazinylmoeity it is not detectable in normal bzd-test.
sementes de gergelim (proprietário verificado) -
Um me interessa. Já que se trata de base livre, deve ser vaporizado no experimento de laboratório?
Rechemco -
Tradução do comentário (Alemão → Inglês):
“One thing interests me. Since it is freebase, does it have to be vaporized in a laboratory experiment?”
Responder em alemão:
Hallo und danke für deine Frage!
Nein, Freebase bedeutet nicht, dass ein Stoff verdampft oder „geraucht“ werden muss. Der Begriff Freebase beschreibt lediglich die chemische Form des Moleküls — also die nicht-salzartige, ungeladene Baseform im Gegensatz zu z. B. HCl-, Sulfat- oder Citrat-Salzen.
In der Forschung wird die Freebase häufig verwendet, weil sie:
eine andere Löslichkeit (z. B. besser in organischen Lösungsmitteln) aufweist,
sich leichter für volumetrische Lösungen oder weitere chemische Umsetzungen eignet,
die Ausgangsform vieler Moleküle in der Synthese ist.
Freebase heißt nicht, dass ein bestimmter Applikations- oder Verdampfungsweg erforderlich oder vorgesehen ist. Die Verwendung hängt ausschließlich vom jeweiligen Laborprotokoll und Forschungsziel ab.
Bitte denk daran, dass alle verkauften Produkte Research Chemicals sind, nicht für den menschlichen oder tierischen Konsum bestimmt. Geeignete Sicherheitsmaßnahmen und eine präzise Waage sind erforderlich.
Responder em inglês:
Olá e obrigado pela sua pergunta!
No — freebase does not mean that a substance must be vaporized or “smoked.” The term freebase simply refers to the chemical form of the compound: the non-salt, uncharged base form, as opposed to salts such as HCl, sulfate, or citrate.
In research settings, the freebase form is often used because it:
has different solubility properties (often better in organic solvents),
can be more suitable for volumetric solutions or further chemical processing,
represents the original form of many molecules after synthesis.
Freebase does not imply any required route of use. How it is handled depends entirely on the laboratory protocol and research purpose.
Please remember that all products sold are Research Chemicals, not intended for human or animal consumption. Proper laboratory safety procedures and a precise scale are required.
honck -
Hallo Dennis,
1. war die lieferzeit vollkommen ok am 9 Tag war mein Brief bei mir!
2. es ist eine sehr schöne Forschungschemikalik
3. Ich werde jketzt nur noch bei Rechemco bestellen
ein großes Lob an Dennis der mir immer alle meine Fragen beantwortet hat!
Lygelll (proprietário verificado) -
Alternativa interessante aos benzos! Clobro é um pouco suspeito. Este FluO supostamente poderia ter alguns vieses de proteína G de um pequeno estudo teórico e a sensação de calor que hipoteticamente proporciona na administração (direto no fb)
Luigi -
Hello everyone, and hello to AqueThaKinq, (from a other Thread in the opioid Category)
Yes, I feel very similar to you. I was always satisfied with this shop and never had any problems. But then the quality of some products started to decline significantly. The other issue was the same as yours: my shipment never arrived. After 2.5 months, I was refunded half of my order, and the other half was supposed to be sent with my next purchase. One half actually arrived without any issues. However, it has now suddenly become mandatory to place a minimum order of 120 EUR, which was not the case before. Dennis shows no understanding that I do not want to spend another 120 EUR just to receive the remaining half of my previous order. And honestly, I don’t even believe the shipment was truly lost. Sad but true. I was a long-term customer here, and when things stop running smoothly, you suddenly feel shamelessly taken advantage of. I really don’t like this development at all.
I also want to clearly emphasize how dangerous these substances are. People, this is not a joke. People die from this. Withdrawal from opioids like these is beyond brutal, and benzodiazepine withdrawal is absolute hell on earth — and that includes Bretazenil. This has absolutely nothing to do with a simple flu or with “willpower.” When you handle these substances carelessly, it can truly open the gates of hell. I was lucky enough to get off benzodiazepines. Unfortunately, I still suffer from occasional panic attacks, social anxiety, and sleep disturbances, which is why I take a benzodiazepine in a very low dose only as rarely as possible and only when there is no other option. But for fun? No. Please take care of yourselves and do not destroy your lives with these substances. Believe me: benzodiazepines are playing with hell. Withdrawal feels like pure apocalypse.
Apparently, having a relatively healthy and cautious attitude toward benzodiazepines is not very welcome here — and probably not very good for business either. Because someone who is deeply dependent on high doses will tolerate anything and spend enormous amounts of money.
I wish you all the very best, good health, and a life where you can be happy without drugs and without addiction 😊
Rechemco -
Hello and thank you for your message.
First of all, we want to clearly state that all our products are Research Chemicals and are not intended for human or animal consumption. We cannot control how individuals choose to use these materials, and any misuse is entirely outside of our responsibility.
Regarding your concerns about quality: the compounds we provide remain consistent in identity and specification. What often changes over time is tolerance, which can significantly alter how effects are perceived. This can sometimes lead to the impression that a product is “weaker,” when in reality the baseline response has shifted.
Concerning the €120 minimum order, this was introduced to reduce a very high volume of small shipments, which created logistical and safety challenges. It also helps us maintain a structure focused on serious and organized research rather than sporadic low-volume requests. We understand that this may not suit everyone, but it is part of our current operational model.
We also want to acknowledge your comments about risk and dependency. You are absolutely right — these are very potent substances, and careless handling can lead to serious consequences. We strongly encourage everyone to approach research with discipline, awareness, and respect for the risks involved.
We appreciate your past support and wish you the best going forward.
Por favor, lembre-se de que todos os produtos vendidos são Produtos Químicos de Pesquisa, não destinados ao consumo humano ou animal. Procedimentos adequados de segurança de pesquisa e uma balança precisa são necessários.
xnjzewdo (proprietário verificado) -
Sufficient reason to give a positive review in my opinion. Decent for all-around purposes. Closest comparison might alprazolam although I believe it is just so slightly milder, but perhaps longer-lasting. Anxiolysis is decent, as is sedation. Muscle relaxation not so much, so would not replace e.g. clonazepam. Biggest downside in my opinion is that the gap between functional anxiolysis and amnesiac effects is relatively small. It does not alter behaviour badly, thus being possible to use as medication for anxiety, but despite remaining “sober”, memory gaps seem to appear at surprisingly low doses. So would not recommend to people such as students or information workers, at least not regularly. But for rare use in low doses, I believe it’s potentially the best one currently available here, albeit not the best in history (pales in comparison to e.g. etizolam, as well as avizafone). Does not require extreme caution like Clobromazolam, which is a good thing. With the caveat that all research use does of course require caution. But Clobromazolam is at least an order or magnitude more dangerous, potentially speaking. So in context, I low-dose use could be called safe and functional, within reason.
Does Dennis know for how long will freebase powder stay good when stored in a dark, dry place in room temperature? Does it have to be soluted very quickly or would months of storage be ok?
Rechemco -
Olá,
Thank you very much for your detailed review and for taking the time to share your research observations. We really appreciate contributions like yours.
Even though this compound is considered more manageable than some of the ultra-potent benzodiazepines, it should never be underestimated. A precision scale, careful handling, and maximum attention are always required when working with compounds in this class.
We would also like to remind researchers that continuous or everyday exposure to benzodiazepines is not advisable. Repeated use can lead to tolerance and dependence, which is why these compounds should only be handled in an appropriate research setting.
Regarding storage, the best way to preserve Research Chemicals is to keep them:
* In a freezer whenever possible.
* Double sealed in zip-lock bags to minimize exposure to air and moisture.
* Stored inside a sealed container (such as a Tupperware box) to protect them from humidity and temperature fluctuations.
* If you have a larger quantity, it is preferable to divide it into several smaller portions. This avoids repeatedly opening the same container, reducing exposure to moisture, oxygen, and temperature changes.
Under these conditions, many compounds remain stable for a long time.
Regarding solutions, freebase compounds are generally **more difficult to dissolve** than their HCl counterparts. Preparing a homogeneous solution may require patience and appropriate solvents, so we generally recommend preparing only the amount needed for the current research rather than making large batches for long-term storage.
Thank you again for your excellent review and your continued support.
Por favor, lembre-se de que todos os produtos vendidos são Research Chemicals, not intended for human or animal consumption. Sempre conduza pesquisas cuidadosamente, use procedimentos laboratoriais apropriados e equipamentos de medição precisos, e nunca subestime a potência desses compostos.