製品概要:

Avizafone, known as Pro-Diazepam, is a water-soluble prodrug of diazepam. Developed by the French military, it primarily serves as an antidote to organophosphate nerve agent poisoning.

作用メカニズム:

Once ingested, avizafone is metabolized in the liver, converting rapidly into diazepam. It is part of a three-drug cocktail, including an anticholinergic and an acetylcholinesterase reactivator, to combat nerve agent effects.

用法・用量:

The typical dose for avizafone in the context of organophosphate poisoning is 20 mg. It is administered alongside other specific antidotes.

Side Effects and Safety:

Side effects are similar to diazepam’s, including amnesia, anxiety, gastrointestinal disturbances, and others. However, considering its use in life-threatening situations, these side effects are less significant.

Harm Reduction and Dependencies:

As a single-use drug in critical scenarios, avizafone has negligible abuse potential and dependency risk. Harm reduction strategies for benzodiazepines in general include avoiding mixing with other depressants and adhering to prescribed dosages.

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