Gabapentin EU

27 - 277 - 277

Gabapentin – Neuromodulation for Pain, Anxiety & Seizures

Gabapentin is a versatile GABA analogue used for neuropathic pain, epilepsy, and anxiety. It acts on calcium channels in the nervous system to reduce nerve overactivity without directly affecting GABA receptors.

  • Powerful neuropathic pain relief
  • Effective seizure control (as add-on therapy)
  • Used off-label for anxiety and insomnia
  • Low addiction risk when used responsibly

Gabapentin is a proven compound in the study of calcium channel modulation, with extensive applications in neuroscience and psychiatry research.

For research use only. Not for human consumption.

Tämä tuote toimitetaan Euroopasta seurantanumerolla.

ATTENTION

Ennen kuin teet tilauksen, sinun on tarkistettava oman maasi päivitetty lainsäädäntö.

Usually you can find the list of the regulated substances on your country .gov website. If you are ordering any scheduled product and it get seized by local customs no complaint or refund.

EMME OLE VASTUUSSA.

SKU: Gabapentin-EU Luokat: ,

Gabapentin is a synthetic analog of gamma-aminobutyric acid (GABA), originally developed as an antiepileptic drug (AED). Though structurally related to GABA, gabapentin does not bind to GABA receptors; instead, it modulates voltage-gated calcium channels by binding to the α2δ subunit. This results in decreased excitatory neurotransmitter release, making it effective in a range of neurological and psychiatric disorders.


Chemical Information

  • IUPAC Name: 1-(aminomethyl)cyclohexaneacetic acid
  • Molecular Formula: C9H17NO2
  • Molekyylipaino: 171.24 g/mol
  • CAS Number: 60142-96-3
  • Drug Class: Anticonvulsant, Neuromodulator

Farmakodynamiikka

Gabapentin does not directly modulate GABA receptors but exerts its effects by binding with high affinity to the α2δ-1 and α2δ-2 subunits of voltage-gated calcium channels (VGCCs). This leads to:

  • Reduced calcium influx in neurons
  • Inhibition of excitatory neurotransmitters like glutamate and substance P
  • Modulation of pain signaling in the spinal cord

Käyttöaiheet

Gabapentin is approved or widely used off-label for:

  • Epilepsy (partial seizures, adjunct therapy)
  • Neuropathic pain (postherpetic neuralgia, diabetic neuropathy)
  • Generalized anxiety disorder (off-label)
  • Fibromyalgia
  • Alcohol withdrawal syndrome
  • Restless Legs Syndrome (off-label)

Annostus ja antaminen

Typical adult dosages vary by condition:

  • Epilepsia: 900–1800 mg/day, in 3 divided doses
  • Neuropaattinen kipu: Start at 300 mg once daily, titrate to 1800–3600 mg/day
  • Anxiety (off-label): 300–1200 mg/day

Titration is critical to minimize side effects, and abrupt discontinuation should be avoided to prevent withdrawal symptoms or seizure rebound.


Farmakokinetiikka

  • Absorptio: Bioavailability is dose-dependent (60% at 300 mg, drops with higher doses)
  • Jakelu: Not significantly protein-bound; crosses the blood-brain barrier
  • Aineenvaihdunta: Not metabolized by the liver
  • Erittyminen: Renal elimination; unchanged
  • Half-life: ~5–7 hours

Sivuvaikutukset

Yleinen:

  • Uneliaisuus
  • Huimaus
  • Ataxia
  • Väsymys
  • Peripheral edema

Rare:

  • Mood changes
  • Suicidal ideation
  • Severe allergic reactions (DRESS syndrome)

Gabapentin may cause dependence in some individuals, especially at high doses or with long-term use. Caution is advised in individuals with a history of substance misuse.


Harm Reduction & Safety

  • Avoid combining with other CNS depressants (e.g., alcohol, benzodiazepines)
  • Renal function should be assessed regularly in chronic users
  • Tapering is necessary to avoid withdrawal symptoms
  • May impair cognitive and motor skills—caution with driving or machinery

Legal Status

  • YHDYSVALLAT: Prescription-only, Schedule V in some states due to abuse potential
  • EU: Prescription-only, not scheduled
  • UK: Controlled (Class C, Schedule 3) due to rising misuse

Research and Emerging Uses

Gabapentin continues to be studied in:

  • Chronic cough
  • Migraine prophylaxis
  • Social anxiety disorder
  • PTSD-related sleep disturbances

Its role in modulating central sensitization makes it a candidate in multiple pain-related and psychiatric conditions.


Päätelmä

Gabapentin is a well-established neuromodulatory agent with a broad therapeutic range. Despite its relatively benign profile, responsible use and harm reduction are essential due to potential misuse and withdrawal risks. For researchers, it offers a powerful tool for studying calcium channel modulation and neuropathic pathways.


🇪🇺 Gabapentin Legal Status in Europe (2025 Overview)

Gabapentin on GABA analog anticonvulsant, primarily prescribed for epilepsy, neuropathic pain, and anxiety. It is not a benzodiazepine or opioid, but it acts on calcium channels, and its off-label use has raised concerns over abuse and dependency.

As a result, its legal status varies significantly across Europe — in some countries it’s prescription-only, while in others it’s been recently reclassified as a controlled substance due to rising misuse.


Prescription-Only (Not Controlled)

In these countries, Gabapentin is a prescription drug, but not classified as a narcotic or psychotropic substance. It’s regulated under standard medical laws:

  • 🇫🇷 France
  • 🇩🇪 Germany
  • 🇪🇸 Spain
  • 🇵🇹 Portugal
  • 🇧🇪 Belgium
  • 🇮🇹 Italy
  • 🇨🇿 Czech Republic
  • 🇸🇪 Sweden
  • 🇫🇮 Finland
  • 🇭🇷 Croatia
  • 🇱🇹 Lithuania
  • 🇪🇪 Estonia
  • 🇦🇹 Austria
  • 🇩🇰 Denmark
  • 🇳🇱 Netherlands

In these cases:

  • Gabapentin is prescribed and dispensed like a typical anticonvulsant.
  • There is no need for special narcotic prescription forms.
  • Monitoring may still exist for suspected abuse cases (e.g. France’s secure prescription tracking system).

🔒 Controlled Substance / Misuse Risk Classification

Some countries have reclassified Gabapentin as a controlled substance, citing growing recreational misuse, especially in combination with opioids or benzodiazepines.

Countries with tightened control:

CountryStatus
🇬🇧 United KingdomSince 2019, Gabapentin is a Class C / Schedule 3 controlled substance under the Misuse of Drugs Act. Requires secure prescription and is subject to dispensing restrictions.
🇮🇪 IrelandClassified under the Misuse of Drugs (Amendment) Regulations 2020. Requires secure prescription and careful monitoring.
🇳🇴 NorwayClassified as a controlled drug under national narcotics legislation. Prescription-only with strict dispensing controls.
🇨🇭 SwitzerlandUnder surveillance but not yet scheduled; some cantons restrict use regionally.
🇸🇰 SlovakiaMoved to controlled substances list due to high misuse rates.
🇭🇺 HungaryControlled; prescription required and monitored.

⚠️ Import, Possession, and Travel

  • Illegal to import or possess Gabapentin without a prescription in any EU country.
  • In countries where it is controlled, you must carry a Schengen narcotic certificate or doctor’s letter when traveling with it.
  • Customs seizures have increased in countries with tightened regulations (e.g., UK, Ireland, Norway).

📝 Schengen narcotic travel certificate info:
https://www.schengenvisainfo.com/schengen-certificate/


💊 Key Risks

  • Gabapentin is often misused recreationally for sedative or euphoric effects.
  • Can potentiate opioids and benzodiazepines — leading to increased overdose risk.
  • Despite being unscheduled in some countries, doctors may still restrict or monitor its use, especially for non-neurological indications.

🧠 Summary Table

Legal StatusCountries
✅ Prescription-only (not scheduled)🇫🇷 🇩🇪 🇪🇸 🇵🇹 🇧🇪 🇮🇹 🇳🇱 🇨🇿 🇸🇪 🇫🇮 🇩🇰 🇦🇹 🇱🇹 🇪🇪 etc.
🔒 Controlled substance🇬🇧 🇮🇪 🇳🇴 🇭🇺 🇸🇰 🇨🇭 (regional)

SPIN TO WIN!

  • Kokeile onneasi ja voita alennuskuponkikoodi
  • 1 ilmaiskierros joka 15. päivä
  • Ei huijausta! Käytä vain oikeaa sähköpostiosoitettasi.
  • MUISTA: Kuponkikoodin voimassaoloaika on 7 päivää.
Kokeile onneasi!
Ei koskaan
Muistuta myöhemmin
Ei kiitos