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Pynazolam – Triazolobenzodiazepine Derivative (Research Use Only)

Descripción general

Pynazolam is a synthetic benzodiazepine derivative of the triazolo-benzodiazepine (TBZD) class. It was first described in the 1970s but was never developed for clinical use.
It has emerged in recent years as a “designer benzodiazepine” / novel psychoactive substance (NPS) and is of interest in forensic toxicology, GABA_A receptor research, and structure-activity relationship (SAR) studies.

Chemical Identity & Structure

• Nombre IUPAC: 1-methyl-8-nitro-6-(pyridin-2-yl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
• Fórmula molecular: C₁₆H₁₂N₆O₂
• Número CAS: 2034366-97-5
• Clase: Triazolobenzodiazepine (TBZD)
• Apariencia: Typically supplied as research grade powder or salt (analytical standard)

Mechanism of Action (Inference)

As a benzodiazepine analog, Pynazolam is presumed to act as a modulador alostérico positivo of the GABA_A receptor. By binding to the benzodiazepine site, it enhances GABA-mediated chloride flux, causing neuronal hyperpolarization and CNS depression.
Designer benzodiazepines of the TBZD class are known to exhibit strong sedative, anxiolytic, muscle-relaxant, hypnotic, and amnestic effects—though the precise pharmacology of Pynazolam remains largely uncharacterised.

Pharmacological & Toxicological Considerations

• There is limited published data on human pharmacokinetics or clinical use of Pynazolam. In silico and experimental modelling suggest high potency, and typical “designer benzodiazepine” risk profiles apply.
• Designer benzodiazepines have been implicated in hospitalisations, impaired driving, and fatalities—especially when used with opioids, alcohol or other depressants.
• Given the unknown therapeutic index and high potency, laboratory handling must assume narrow margin between effect and toxicity.

Analytical & Forensic Applications

Pynazolam can be used as a reference compound in:

• LC-MS/MS and GC-MS method validation for designer benzodiazepine detection
• Forensic toxicology screening of NPS-related intoxications
• SAR studies exploring how the 8-nitro and pyridinyl substitutions affect receptor binding and metabolism

Safety, Handling & Laboratory Precautions

• Use only in licensed, well-equipped laboratories
• Employ PPE: gloves, eye protection, respirator (if aerosol risk)
• Use analytical precision balances and avoid cross-contamination
• Dispose in compliance with institutional chemical hazard protocols
• Label clearly: For Analytical/Forensic Use Only – Not for Human Consumption

Legal & Regulatory Status

• Pynazolam is an unapproved psychoactive substance. Many jurisdictions regulate designer benzodiazepines under analogue laws or specific controls.
• Researchers must verify local controlled-substance classification and institutional compliance prior to acquisition or use.

Resumen

Pynazolam is a potent triazolobenzodiazepine analogue with forensic and pharmacological significance. Its structural modifications (8-nitro group, pyridinyl substitution) make it relevant for GABA_A receptor studies and designer benzodiazepine monitoring. Given its unknown human profile and high potency, it demands rigorous analytical handling and is strictly for research use.

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Qué recibirá al comprar Pynazolam de RECHEMCO?

- Una bolsa de papel de aluminio sellada que contiene Pynazolam
• white/yellowish powder
• Pureza 99%