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Modafinil is an eugeroic drug. It is approved by the United States' Food and Drug Administration (FDA) for the treatment of narcolepsy, shift work sleep disorder and excessive daytime sleepiness associated with obstructive sleep apnea. Despite extensive research into the interaction of modafinil with a large number of neurotransmitter systems, its precise mechanism or mechanisms of action remain unclear.Modafinil elevates hypothalamic histamine levels, leading some researchers to consider modafinil a "wakefulness promoting agent" rather than a classic amphetamine-like stimulant. Modafinil seems to inhibit the actions of the dopamine transporter, thus leading to an increase in extracellular and thus synaptic concentrations of dopamine.
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